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Lack of Motivation May be Due to Inflammation

902 inflammation kills motivation

Many of us are pretty good at beating ourselves up when we have lost our motivation, calling ourselves lazy or worthless. But research shows laziness, or lack of motivation, can actually be a symptom of chronic inflammation.

A natural state of health is to want to engage in life. If you don’t want to and don’t care, this is a red flag to look for an underlying health condition.

New research shows that chronic low-grade inflammation hinders the activity of areas in the brain responsible for motivation.

Called the dopaminergic signaling system, these parts of the brain rely on sufficient dopamine, a brain chemical responsible for motivation, drive, and a sense of self-worth — hence the feelings of worthlessness that often accompany low motivation or “laziness.”

The hypothesis is that when the body is suffering from chronic inflammation, this means it has an injury or illness it must heal. In order to meet the demands for healing, the brain lowers drive and motivation so that energy is freed up for healing.

Our everyday tasks and chores, or working toward our goals and dreams suddenly no longer feel worth it.

That’s because inflammation has down regulated areas of the brain that link a sense of reward to effort and work.

We can especially feel this when we are laid up with the flu or a bad injury that can make watching Netflix tiring.

However, low-grade chronic inflammation is not just about the flu or an injury anymore. It is an epidemic problem these days, as evidenced by the mushrooming incidences of chronic inflammatory disorders, such as heart disease, obesity, diabetes, autoimmune disease, and cancer.

In fact, many brain-based disorders are often a consequence of inflammation, including depression, anxiety, fatigue, memory loss, brain development disorders in children, and even acute psychiatric conditions.

Understanding the cause of no motivation can lift shame and stigma

Because chronic illness and inflammation causes lack of motivation and fatigue, sufferers are often stigmatized for their condition.

The majority of people with chronic illness are women, and they are commonly dismissed or disbelieved by doctors in the standard health care model or even by their own families.

What’s worse, many internalize the stigmatization and suffer in isolation and with shame around their low energy and lack of motivation.

That’s why it’s important to understand “laziness” and lack of motivation can be symptoms of a larger, underlying problem and not character flaws.

Why is modern life so inflammatory?

Compared to our ancestors and many people on the planet today, many Americans have it pretty easy in terms of ease and convenience.

Yet why are we so inflamed and chronically ill?

Here are just a few factors driving epidemic levels of chronic inflammation and illness:

Blood sugar is too high. Advertising, restaurants, grocery store aisles — everything about modern life is hellbent on making us gorge on sugar and processed carbohydrates. However, science shows high blood sugar is one of the most common and relentless sources of chronic inflammation.

Modern foods are pro-inflammatory. Gluten intolerance is responsible for more inflammation than people realize, thanks to modern hybridization, storing, and pesticide use of gluten grains and other grains. Industrialized fats such as canola oil, soybean oil, and hydrogenated fats are recognized as inflammatory and are ubiquitous in the food supply.

People eat too little produce. Americans eat about half the amount of fiber they should to be healthy. A diet rich in plant fibers creates a gut microbiome rich in healthy gut bacteria. Bad gut bacteria and an unhealthy microbiome are pro-inflammatory and pro-disease.

Modern life is sedentary. Except for workers whose jobs are physical, our ultra-convenient, screen-based lives are extremely sedentary. Lack of regular physical activity and “sitting disease” are sources of chronic inflammation.

Modern life is toxic. Numerous studies link numerous toxins to inflammatory-based conditions. Plastics, pesticides, car exhaust, scented cleaning products, chemically laden body products and foods — we live in a sea of environmental toxins and heavy metals the body was not designed to manage. We are also exposed to too much artificial light, which confuses our biological rhythms and triggers inflammation.

People are stressed out. Despite our many comforts and conveniences, rates of depression, anxiety, and stress are high and afflicting younger and younger people. These negative emotions are known triggers of inflammation. When you experience them all the time, it can lead to inflammatory-based health disorders.

How functional medicine can help you restore your natural motivation

Although we are up against many daunting assaults on our physiology, functional medicine recognizes this and has strategies and protocols to help you.

One of the most common rewards of a functional medicine dietary, lifestyle, and nutritional game plan is the return of energy, motivation, and ambition.

“Laziness” and lack of motivation are red flags. Ask us how we can help you remedy them.

Depression is a Disorder of Inflammation in Many Cases

849 depression and inflammation

Depression is one of the most common mental disorders in the United States, affecting more than 16 million people. As such, antidepressant use has jumped by 65 percent in the last 15 years, with one in eight Americans over the age of 12 taking antidepressants.

These statistics are alarming considering the root causes of depression are going unaddressed. Like pain or injury anywhere in the body, depression is a warning flag from the body that the system is out of balance. Stamping out the root causes of depression is like removing the engine light in your car instead of investigating what’s wrong with the car.

In functional medicine we look at the body as an integrated whole, with all parts working together and influencing one another. If you understand human physiology, it doesn’t make sense to isolate and treat one part of the body — such as the brain in depression — without including the overall health of the body.

Many factors can play into depression, including blood sugar imbalances, hormonal imbalances, immune dysregulation, gut health, and gut microbiome dysfunctions.

All of these factors can lead to brain inflammation, which scientists are increasingly finding is the most common cause of major depressive disorder. This type of depression does not respond to antidepressants.

Antidepressants target brain chemicals. called neurotransmitters, that govern mood, motivation, behavior, and mental activity. Some natural remedies, such as 5-HTP or Saint John’s Wort, also target neurotransmitters.

However, this model does not take into account newer research that shows depression is usually due to inflammation. Inflammation in the brain disrupts brain function in several ways that leads to depression.

Brain inflammation slows firing between neurons

Your brain operates through communication, or firing, between neurons. However, when the brain becomes inflamed, the inflammation slows down conduction between neurons. Slowed firing between neurons in the frontal and limbic lobes of the brain leads to depression.

Brain inflammation prevents the production of neurotransmitters

Feeling happy and content instead of depressed depends on proper neurotransmitter production and activity in the brain. Brain inflammation has been shown to sabotage the synthesis of dopamine and serotonin, the two neurotransmitters most associated with depression.

Dopamine is called the “pleasure and reward” neurotransmitter. Symptoms of low dopamine include:

  • Inability to handle stress
  • Inability to self-motivate
  • Inability to start or finish tasks
  • Feelings of worthlessness
  • Feelings of hopelessness
  • Short temper over minor upsets
  • Isolating oneself from others
  • Unexplained lack of concern for family and friends

Serotonin is the “joy and well-being” neurotransmitter. Symptoms of low serotonin include:

  • Feelings of depression
  • Feelings of inner rage and anger
  • Difficulty finding joy from life’s pleasures and favorite activities
  • Depression when it is cloudy or when there is lack of sunlight
  • Not enjoying friendships and relationships
  • Not enjoying favorite foods
  • Unable to fall into deep restful sleep

As dopamine levels drop, you lose your motivation and drive. As serotonin drops, you lose your mood, sense of happiness, and satisfaction with things you used to love.

While this may look like a neurotransmitter problem, antidepressants typically have no effect because they do not address the brain inflammation causing it.

Brain inflammation prevents neurotransmitter receptor sites from working well

Brain inflammation also inhibits the function of receptor sites on neurons for neurotransmitters. Even if there is enough dopamine or serotonin in the brain, brain inflammation will prevent receptors from responding to them appropriately. This prevents neurons from communicating with one another efficiently and depression results.

Brain inflammation and depression are signs the brain is degenerating too fast

The brain is made up of two types of cells: neurons and microglia cells. Microglia cells are the brain’s immune cells and facilitate healthy neuron function, respond to foreign invaders, and clean up plaque and debris.

However, the brain’s immune cells don’t have an off-switch like the body’s. When they are triggered by a brain injury, an inflammatory food, unstable blood sugar, a chronic infection, poor gut health, infectious bacteria in the gut, chronic stress, alcohol abuse, and other insults, they become over-activated in an effort to protect the brain. Unfortunately, they don’t necessarily turn off afterward and can stay in a “primed” over active state indefinitely if constantly triggered by poor dietary and lifestyle choices. This is what causes brain inflammation and depression.

I hope you can see now why so many people don’t respond to antidepressants and why it’s so important to address the root causes of depression. Failing to do so allows brain inflammation to continue unchecked, raising the risk of dementia, Alzheimer’s, Parkinson’s, and other brain degeneration diseases. Ask my office how functional medicine can help you tame brain inflammation and overcome depression.

How to Support Your Brain’s Happiness Chemical

836 serotonin basics

Many people take SSRI antidepressants for depression. However, it’s important to ask why you are feeling depression in the first place.

Many important research strides have been made linking chronic inflammation, poor gut health, gut bacteria, and general brain health with depression.

However, we still need healthy serotonin activity, the target of SSRIs, to feel good.

Do you have these symptoms of low serotonin?

  • No longer finding joy, pleasure, or enthusiasm in life
  • Rage and anger
  • Depression
  • Depression related to lack of sunlight
  • No longer enjoy hobbies, favorite foods, friendships, or relationships
  • Unable to sleep deeply or feel rested from sleep
  • Life looks good on paper but doesn’t feel good

Light. The brain depends on sufficient light to manufacture serotonin, so being indoors all the time or in chronically dark or grey weather can affect serotonin activity.

Estrogen. In women an estrogen deficiency can lead to poor serotonin activity. This can explain why some women who are perimenopausal or post-menopausal experience depression.

Although it’s important to use functional medicine to address the cause of low estrogen, such as blood sugar or adrenal imbalances, some perimenopausal or post-menopausal women may still need bioidentical hormone replacement. In these situations, estrogen therapy can deplete the methyl donors necessary for serotonin synthesis, making it important to supplement with them: methyl B-12, SAMe, or MSM (methylsulfonylmethane).

Diet. Some nutritional advice will tell you to address low serotonin activity with foods high in tryptophan, a precursor amino acid to serotonin. However, clinically we really don’t see this work.

Better nutritional advice is to eat a diet that keeps blood sugar stable and does not inflame the gut or the body. This means avoiding sugar and processed carbohydrates, avoiding foods that trigger an immune response, and eating lots of diverse vegetables to foster healthy and diverse gut bacteria.

Blood sugar and gut inflammation. Unstable blood sugar — blood sugar that is either too low or too high — can significantly impact serotonin activity, leading to depression. The same goes for a diet that inflames the gut and the body.

Iron. Additionally, an iron is deficiency can cause low serotonin production. Things that can cause iron deficiency include iron anemia, celiac disease, leaky gut, heavy periods, parasites, over exercising, low stomach acid, hypothyroidism, and uterine fibroids.

Nutritional cofactors for serotonin activity

In addition to iron, nutrients serotonin synthesis requires include P-5-P (pyridoxal-5-phosphate), an active form of B-6, niacin, methyl B-12, folic acid, and magnesium.

Deficiencies in these cofactors are widespread due to how poorly most Americans eat.

Additionally, magnesium deficiencies can arise in those taking diuretics or athletes who over train.

Methyl donors such as methyl B-12 are important for the conversion of the amino acid 5-HTP to serotonin; people who take SSRI antidepressants for long periods of time deplete their methyl donors and P-5-P.

Those considering weaning off SSRIs may need to supplement with these cofactors to cover deficiencies acquired during use of the medication.

Supplements that support serotonin activity

The amino acids 5-HTP or tryptophan are precursors to serotonin. Tryptophan has been shown to more easily cross the blood-brain barrier than 5-HTP. Others prefer 5-HTP because it is only one step away from being converted to serotonin, whereas tryptophan is two steps away. Therefore, 5-HTP has more potential to boost serotonin levels. However, both work and taking both can cover your bases.

Both 5-HTP and tryptophan have been shown to be helpful in addressing depression, persistent nightmares, fibromyalgia, chronic headaches, migraines, and mood disorders.

Botanicals that increase receptor site sensitivity, ensure the breakdown of used serotonin, and provide necessary cofactors for serotonin production include St. John’s wort, SAMe, P-5-P (a form of B-6), niacinamide, magnesium citrate, methyl B-12, and folic acid.

Ask my office how we can help you support your brain serotonin activity so it can help you feel happier and enjoy life more.

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